Running title: β-tubulin VI variability and paclitaxel toxicity
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چکیده
1 Title: Hematologi β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity. Authors: Luis J. Leandro-García, Susanna Leskelä, Lucia Inglada-Perez , Iñigo Landa, Aguirre A de Cubas, Agnieszka Maliszewska, Iñaki Comino-Méndez, Rocío Letón, Álvaro Gómez-Graña, Raúl Torres, Juan Carlos Ramírez, Sara Alvarez, José Rivera, Constantino Martinez, Maria Luisa Lozano, Alberto Cascón, Mercedes Robledo and Cristina Rodríguez-Antona Affiliations: 1 Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain. 2 Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 3 Viral Vector Unit, Spanish National Cardiovascular Research Centre (CNIC), Madrid, Spain 4 Molecular Cytogenetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Madrid, Spain. 5 Centro Regional de Hemodonación, University of Murcia, Spain. Type of manuscript: Research Article
منابع مشابه
Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity.
Cellular microtubules composed of α-β-tubulin heterodimers that are essential for cell shape, division, and intracellular transport are valid targets for anticancer therapy. However, not all the conserved but differentially expressed members of the β-tubulin gene superfamily have been investigated for their role in these settings. In this study, we examined roles for the hematologic isoform β-t...
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تاریخ انتشار 2012